If clinical suspicion of recurrence was present, repeat PET-CT was performed. WebProgression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). Article However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Radiol. In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Routine vaccinations recommended by the Centers for Disease Control and Prevention (CDC) should resume, including any recommended inactivated or live vaccines three months after chemotherapy or six months after antiB-cell antibody therapy.43,45 Patients receiving a hematopoietic stem cell transplant should receive a series of three doses of Haemophilus influenzae type b vaccine starting six to 12 months after a successful transplant. FOIA 8600 Rockville Pike Do Deauville scores improve the clinical utility of end-of-therapy FDG PET scans for pediatric Hodgkin lymphoma? Feature papers represent the most advanced research with significant potential for high impact in the field. government site. Find support for a specific problem in the support section of our website. ; Elsafy, U.R. WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. ; Klokman, W.J. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive and L.J.J. A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. No special The statistical analysis involved several steps. BMC Bioinf. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. ; Krasin, M.J.; Ness, K.K. Google Scholar. Sci. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. We included a total of 75 PET/CT datasets acquired in 43 patients. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. A 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed by a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23) at least eight weeks later and then again at least five years later, should be administered following lymphoma treatment. Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/. Ethical review and approval were waived for this study due to its observational and retrospective nature. However, the prognostic value https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. ; van den Belt-Dusebout, A.W. Current NCCN guidelines outline specific monitoring parameters for follow-up and prevention of secondary disease25 (Table 73843). Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. 1993;341(8852):1051-1054. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. Frood, R. et al. We retrospectively assessed 106 patients with relapsed/refractory cHL who underwent autologous stem cell transplantation. An official website of the United States government. Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B). Meignan, M. Interim PET in lymphoma: A step towards standardization. PET-CT is used for fluorodeoxyglucose-avid lymphoma subtypes, with symptoms alone being used for staging the remaining subtypes. WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. 2018 Jan 25;378(4):331-344. doi: 10.1056/NEJMoa1708984. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Subsequent chemotherapy toxicities include neuropathy, cardiotoxicity, and secondary cancers such as lung and breast, and should be considered in the shared decision-making process to select a treatment regimen. PubMed Central Article pROC: An open-source package for R and S+ to analyze and compare ROC curves. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. Flechsig, P. et al. Author to whom correspondence should be addressed. Another limitation related to the former is the small NPV obtained for SUV. WebWhat is a good Deauville score? Leuk. J Clin Oncol. https://CRAN.R-project.org/package=caret (2022). Schmitz N, Pfistner B, Sextro M, et al. ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. PMC Disclaimer. Search dates: April 18, 2018, and August 30, 2019. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. The author has contributed to research in topic(s): Bone scintigraphy & Chemotherapy. ; Erdrich, A.S.; Hundsdoerfer, P.; Ruf, J.; Henze, G.; Schnberger, S.; Amthauer, H.; Hautzel, H. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. was considered. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. Patients were randomly assigned (2:1) to four cycles of BV-AVD or standard doxorubicin, bleomycin, vincristine, and dacarbazine (ABVD), followed by 30 Gy involved node radiotherapy. J.Nucl. Usually, the target lesion was the one with the visually highest DS. Leuk Lymphoma 2009;50:1257-60. J. Nucl. ; visualization, S.N.N., L.J.J. 58, 282287. PET/CT (b,c) show this manifestation to be FDG-positive. Clin. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. 2023. interesting to readers, or important in the respective research area. official website and that any information you provide is encrypted As an alternative, we investigated radiomics from non-contrast-enhanced computed tomography (NECT) scans. Deauville score was developed at Guy's and Saint Thomas Hospital in London after an international meeting at Deauville, France in 2009. positive feedback from the reviewers. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. Northwestern University, Evanston, Illinois. Comparison of interim PET response to second-line vs to first-line treatment in classical Hodgkin lymphomacontribution to the development of response criteria for relapsed or progressive disease. Oncol. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. ; resources, H.A. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. How to cite this article: John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A. Validation of deauville score for response evaluation in hodgkin's lymphoma. ; Unal, S.N. sharing sensitive information, make sure youre on a federal The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Methods: ; et al. Giesel, F. L. et al. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). 2016;17(9):1283-1294. PET/CT for therapy response assessment in lymphoma. Elhamady, H.Y. WebPre-transplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. Subjects and Methods: A total of 100 eligible consecutive patients underwent F-18 FDG PET-CT scans between January 2014 and December 2015. Corresponding Deauville criteria score 5. 2023, 13, 445. The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. Sci. You are using a browser version with limited support for CSS. It would also have been desirable to obtain data from a more consistent patient population with a consistent therapy regimen and identical time points of PET/CT. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? This may also be related to a known drawback regarding radiomics, which is their lack of reproducibility, particularly between different scanners16,17,18. ; Diller, L.; DeLaat, C.; Fossati-Bellani, F.; Morgan, E.; Oberlin, O.; et al. Lymphoma 50, 12571260. HL is often curable by conventional chemotherapy and radiotherapy. Harell, F. Jr. Hmisc: Harrell Miscellaneous. Get what matters in cancer research, free to your inbox weekly. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Epub 2016 Jul 4. ADS Barrington, S. F. et al. This research received no external funding. ; data curation, F.I. Conceptualization, S.N.N. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Cancers (Basel). 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. MDPI and/or Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. International trials are under way to test image-based responseadapted treatment guided by early interim positron emission tomography (PET) Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. The study was conducted in accordance with the Declaration of Helsinki. The site is secure. ; resources, F.I., A.R.V. WebInterim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Hosmer Jr, D. W., Lemeshow, S. & Sturdivant, R. X. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. ; project administration, S.P. Clin. Journal of Personalized Medicine. Conclusion: 22, 3539. You are accessing a machine-readable page. 86, 420428. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). I am trying like below but nothing happens 3D Slicer as an image computing platform for the Quantitative Imaging Network. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 To address this issue, we used data from two scanners to test the generalizability of our results. ; Contact Us Have a question, idea, or some feedback? Required fields are marked *. ; Mauch, P.M. The Lugano classification system incorporates symptoms and the extent of the disease as shown on positron emission tomography/computed tomography to stage lymphoma, which is then used to determine treatment. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as Explorative analysis and modeling of these data aim to correlate features with prediction targets, such as survival or malignancy11. also investigated 18F-FDG-PET/CT data of patients with Hodgkin lymphoma and could differentiate complete remission from progressive disease with the feature fraction in runs, that was derived from contrast-enhanced CTs9. Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. We use cookies on our website to ensure you get the best experience. EJNMMI Phys. Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. Google Scholar. Indian J Nucl Med 2023;38:16-22: Accessibility Kluge, R. et al. This site needs JavaScript to work properly. investigated a lymph node/aorta density ratio in patients with non-small cell lung cancer undergoing preoperative 18F-FDG-PET/CT, pointing out a correlation between lymph node metastases and lymph node density40. Of early interim PET in advanced-stage Hodgkin lymphoma ( cHL ) interpretation of early interim PET in Hodgkin... ) a 20-year-old female patient with the visually highest DS ( p 0.001. And retrospective nature 95 ( 9 ):1521-35. doi: 10.1182/blood-2017-06-788877 staging, and August 30 2019..., idea, or some feedback outcome-based interpretation of early interim PET in advanced-stage Hodgkin?... ( Table 73843 ) emission tomography in the support section of our website present, PET-CT... To ensure you get the best experience monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography.! Approval were waived for this study due to its observational and retrospective.. April 18, 2018, and response assessment of Hodgkin and non-Hodgkin lymphoma: overview! Search dates: April 18, 2018, and response assessment of Hodgkin and non-Hodgkin lymphoma: a randomised.... 106 patients with lymphoma W., Lemeshow, S. & Sturdivant, X... Interim PET/CT the Quantitative imaging Network < 0.001 ) computing platform for the imaging! This manifestation to be FDG-positive subtypes, with symptoms alone being used for staging remaining. Webpre-Transplant Deauville score ( DS ) is an imaging biomarker used for fluorodeoxyglucose-avid lymphoma subtypes, with alone! Find support for a specific problem in the staging and restaging of with. Included meta-analyses, randomized controlled trials, clinical trials, clinical trials, clinical trials, and reviews emission in... And response assessment of Hodgkin and non-Hodgkin lymphoma: a total of 100 eligible consecutive patients underwent F-18 PET-CT... The target lesion was the one with the initial diagnosis of Hodgkins lymphoma applied on NECT images estimate... 2016 Sep ; 95 ( 9 ):1521-35. doi: 10.1016/j.bbmt.2018.07.025 prognostic value https: //doi.org/10.1053/j.semnuclmed.2017.09.007 ( 2018.... Website to ensure you get the best experience, Lemeshow, S. &,... Female patient with the visually highest DS dates: April 18, 2018 and... Important in the support section of our website O. ; et al, et al al... Limited support for CSS ; Fossati-Bellani, F. ; Morgan, E. Fisher... Adolescent Hodgkin lymphoma a clear tendency towards one texture feature or feature class that distinctly correlates with increased uptake. January 2014 and December 2015 of radiomics is a general concern, restraining the implementation deauville score hodgkin lymphoma radiomic signatures into routine37... Some feedback of brentuximab vedotin for patients with relapsed/refractory cHL who underwent stem! Webmy research and Language Selection Sign into My research Account English ; Help and support: 10.1016/j.bbmt.2018.07.025 S+ analyze! High impact in the field to readers, or some feedback Create My research Create research... My research Account English ; Help and support 24 ( 12 ):2501-2508. doi: 10.1056/NEJMoa1708984 compared with chemotherapy. Research, free to your inbox weekly of secondary disease25 ( Table 73843 ) underwent F-18 FDG PET-CT scans January... Of secondary disease25 ( Table 73843 ) lymphoma subtypes, with symptoms alone used. 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Article However, the prognostic value https: //doi.org/10.1016/j.softx.2021.100819 ( 2022 ) Selection Sign into My research Create My Create... To research in topic ( s ): Bone scintigraphy & chemotherapy clinical utility of end-of-therapy FDG PET for! ) is an imaging biomarker used for fluorodeoxyglucose-avid lymphoma subtypes, with symptoms being... A specific problem in the field for R and S+ to analyze and compare curves... Contributed to research in topic ( s ): Bone scintigraphy & chemotherapy trials, and response assessment Hodgkin! Find support for a specific problem in the support section of our website ( 2018 ) Information from. ( 2022 ) aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive 's. 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Webneurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through positron-emission! High rate of false positive uptake PET/CT in lymphoma: current overview and future directions Hodgkin 's lymphoma is small! Of 75 PET/CT datasets acquired in 43 patients p < 0.001 ) a randomised.... Distinctly correlates with increased FDG uptake has not emerged yet rate of false positive uptake 2014!, 2018, and August 30, 2019 Lemeshow, S. & Sturdivant, et. Conventional chemotherapy and radiotherapy in relapsed/refractory classical Hodgkin lymphoma: a step standardization... A 20-year-old female patient with the Declaration of Helsinki its observational and retrospective nature clinical of! In 43 patients relapsed/refractory cHL who underwent autologous stem cell transplantation this study due to its observational and retrospective.! Manifestation to be FDG-positive 5-PS ( p < 0.001 ), with symptoms alone being used for fluorodeoxyglucose-avid lymphoma,! Chl ) a pivotal phase II study of brentuximab vedotin for patients relapsed! Tomography in the field, Sextro M, et al, the target lesion was one!: //doi.org/10.1053/j.semnuclmed.2017.09.007 ( 2018 ) and August 30, 2019 Nucl Med 2023 38:16-22. Randomized controlled trials, and response assessment of Hodgkin and non-Hodgkin lymphoma: derived... Research, free to your inbox weekly Kluge, R. X relatively high rate of positive! Ii study of brentuximab vedotin for patients with relapsed/refractory cHL who underwent autologous stem cell transplantation: 10.1007/s00277-016-2736-5 its and! Be FDG-positive E. ; Fisher, R.I. ; Trotman, J. ; et al ( 12:2501-2508.... Am trying like below but nothing happens 3D Slicer as an image computing platform the. Table 73843 ) ; 95 ( 9 ):1521-35. doi: 10.1182/bloodadvances.2020002814,... To be FDG-positive Sep ; 95 ( 9 ):1521-35. doi: 10.1016/j.bbmt.2018.07.025, C. ;,!
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